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AIE Research

In 2001, Ben Zhong Tang found that 1-methyl-1,2,3,4,5-pentaphenylsilile does not emit light in acetonitrile. However, it emits strong green fluorescence in an acetonitrile solution containing large amounts of poor solvent (water). This phenomenon led Tang to propose the concept of aggregation-induced emission (AIE). Through subsequent research, he theorized and verified the mechanism behind AIE, called the restriction of intramolecular motion (RIM). Tang's work pioneered a new field of research. Based on the RIM mechanism, researchers constructed a large number of structurally diverse small molecules, polymers, and organometallic complexes with AIE characteristics.

Since the concept of AIE was first proposed, it has gradually grown from an idea to a field of science that attracts dedicated researchers from around the world. Many research articles and reviews have been published over the past two decades. Though several works have provided a literature overview publications of this field, as database developer, our ASBase team updated the publication statistics and analysis of the AIE researches to 2023, based on the data collected from the Web of Science Core Collection with our search strategies.

Overview of Publications

From 2001 to 2022, AIE-related research publications continued to increase rapidly. Until 2023, the total number of relevant publications from Web of Science has reached 28,000. Starting from 2013, the annual growth rate of publications also reveals an increasing trend, reflecting that AIE is an emerging field with sustained growth.


Most Cited Papers
With the increase in the number of publications, the number of citations increased accordingly. The following are the top 20 most cited papers (from 2001 to 2023) in the field of AIE and generalized aggregated science:

1. Luo, J. et al. (2001) ‘Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole’, Chemical communications (Cambridge, England). Royal Society of Chemistry (RSC), (18), pp. 1740–1741. doi: 10.1039/b105159h.

2. Mei, J. et al. (2015) ‘Aggregation-induced emission: Together we shine, united we soar!’, Chemical reviews. American Chemical Society (ACS), 115(21), pp. 11718–11940. doi: 10.1021/acs.chemrev.5b00263.

3. Hong, Y., Lam, J. W. Y. and Tang, B. Z. (2011) ‘Aggregation-induced emission’, Chemical Society reviews. Royal Society of Chemistry (RSC), 40(11), pp. 5361–5388. doi: 10.1039/c1cs15113d.

4. Hong, Y., Lam, J. W. Y. and Tang, B. Z. (2009) ‘Aggregation-induced emission: phenomenon, mechanism and applications’, Chemical communications (Cambridge, England). Royal Society of Chemistry (RSC), (29), pp. 4332–4353. doi: 10.1039/b904665h.

5. Mei, J. et al. (2014) ‘Aggregation-induced emission: the whole is more brilliant than the parts’, Advanced materials (Deerfield Beach, Fla.). Wiley, 26(31), pp. 5429–5479. doi: 10.1002/adma.201401356.

6. Jin, R. et al. (2016) ‘Atomically precise colloidal metal nanoclusters and nanoparticles: Fundamentals and opportunities’, Chemical reviews. American Chemical Society (ACS), 116(18), pp. 10346–10413. doi: 10.1021/acs.chemrev.5b00703.

7. Hong, G., Antaris, A. L. and Dai, H. (2017) ‘Near-infrared fluorophores for biomedical imaging’, Nature biomedical engineering. Springer Science and Business Media LLC, 1(1), p. 0010. doi: 10.1038/s41551-016-0010.

8. Yang, Z. et al. (2017) ‘Recent advances in organic thermally activated delayed fluorescence materials’, Chemical Society reviews. Royal Society of Chemistry (RSC), 46(3), pp. 915–1016. doi: 10.1039/c6cs00368k.

9. Wu, J. et al. (2011) ‘New sensing mechanisms for design of fluorescent chemosensors emerging in recent years’, Chemical Society reviews. Royal Society of Chemistry (RSC), 40(7), pp. 3483–3495. doi: 10.1039/c0cs00224k.

10. Ding, D. et al. (2013) ‘Bioprobes based on AIE fluorogens’, Accounts of chemical research. American Chemical Society (ACS), 46(11), pp. 2441–2453. doi: 10.1021/ar3003464.

11. Chi, Z. et al. (2012) ‘Recent advances in organic mechanofluorochromic materials’, Chemical Society reviews. Royal Society of Chemistry (RSC), 41(10), pp. 3878–3896. doi: 10.1039/c2cs35016e.

12. Wong, M. Y. and Zysman-Colman, E. (2017) ‘Purely organic thermally activated delayed fluorescence materials for organic light‐emitting diodes’, Advanced materials (Deerfield Beach, Fla.). Wiley, 29(22), p. 1605444. doi: 10.1002/adma.201605444.

13. Du, X. et al. (2015) ‘Supramolecular hydrogelators and hydrogels: From soft matter to molecular biomaterials’, Chemical reviews. American Chemical Society (ACS), 115(24), pp. 13165–13307. doi: 10.1021/acs.chemrev.5b00299.

14. Spano, F. C. (2010) ‘The spectral signatures of Frenkel polarons in H- and J-aggregates’, Accounts of chemical research. American Chemical Society (ACS), 43(3), pp. 429–439. doi: 10.1021/ar900233v.

15. Luo, Z. et al. (2012) ‘From aggregation-induced emission of Au(I)-thiolate complexes to ultrabright Au(0)@Au(I)-thiolate core-shell nanoclusters’, Journal of the American Chemical Society. American Chemical Society (ACS), 134(40), pp. 16662–16670. doi: 10.1021/ja306199p.

16. Hu, R., Leung, N. L. C. and Tang, B. Z. (2014) ‘AIE macromolecules: syntheses, structures and functionalities’, Chemical Society reviews. Royal Society of Chemistry (RSC), 43(13), pp. 4494–4562. doi: 10.1039/c4cs00044g.

17. Chen, J. et al. (2003) ‘Synthesis, light emission, nanoaggregation, and restricted intramolecular rotation of 1,1-substituted 2,3,4,5-tetraphenylsiloles’, Chemistry of materials: a publication of the American Chemical Society. American Chemical Society (ACS), 15(7), pp. 1535–1546. doi: 10.1021/cm021715z.

18. Kwok, R. T. K. et al. (2015) ‘Biosensing by luminogens with aggregation-induced emission characteristics’, Chemical Society reviews. Royal Society of Chemistry (RSC), 44(13), pp. 4228–4238. doi: 10.1039/c4cs00325j.

19. Liu, J., Lam, J. W. Y. and Tang, B. Z. (2009) ‘Acetylenic polymers: syntheses, structures, and functions’, Chemical reviews. American Chemical Society (ACS), 109(11), pp. 5799–5867. doi: 10.1021/cr900149d.

20. Salinas, Y. et al. (2012) ‘Optical chemosensors and reagents to detect explosives’, Chemical Society reviews. Royal Society of Chemistry (RSC), 41(3), pp. 1261–1296. doi: 10.1039/c1cs15173h.
Research Topics

In the past decades, originated from a special experimental phenomenon, AIE research was gradually expanded to a various of applications. We have extracted frequent keywords from the article titles to create a word cloud plot, which shows that scientists have not only discussed the phenomenon, principles, and luminescence mechanisms of AIE, but have also expanded the application boundary of AIE-based materials to fluorescent probes, bio-imaging, sensing, theranostic, electronic devices. The composition of materials was no longer limited to organic small molecules. Diverse “aggregated” forms have been synthesized and discussed, including polymers, supramolecules, gels, solids, nanoparticles, and more.


Countries / Regions

Originated from Chinese scientist, the field of AIE has attracted dedicated researchers from around the world. In our statistics, more than 40,000 researchers from 118 countries and regions are engaged in the AIE and related fields. The following figure shows the 15 countries and regions with the most amounts of publications in the AIE field.


Institutions & Journals

The following figures, based on our statistics, shows the top 20 active institutions in the AIE field and the 20 journals with the most amounts of related articles.


Related Disciplines

AIE research has generalized to various disciplines. The following figure shows the disciplines corresponding to the active journals.


Productive Authors

From 2001 to 2023, the achievements of some scholars have had a profound academic impact on the AIE field. The following figure shows the 20 most productive authors with AIE publications.